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Changing Patterns in Drug Delivery


For decades, the predominant delivery method [[wysiwyg_imageupload:157:]]
for pharmaceutical products has been oral tablets, capsules or liquids, with the fewer, less complicated doses a day the better. 

If a new medication was introduced requiring four doses a day, competitors would strive to develop a drug requiring three or two or even only one dose a day.  If it could be taken any time of day with or without food or other drugs it was even better.  Fewer daily doses were invariably said to improve compliance because there were fewer doses to miss.  It should be noted, though, that these were “small molecule” drugs – ones developed using chemistry that either because of their own properties or through formulation manipulation could be absorbed through the digestive tract into the body.  Not surprisingly, according to a recent article in Drug Development and Delivery, of the medications currently available in the United States, 7,468 are oral and less than 3,000 are injectable.  (Topical, ophthalmic and other routes are far less prevalent.)  Read full post »